Access Denied Drive

[Aelita]

OK, I have an external hard drive, and I've had it for about 4 or 5 months, and I have a ton of data on it! But now I can't access it! It shows up in the computer window, but there is no memory bar thing like there is for the main drive, when I go to properties, it says there is no memory on it, no used, no available.
When I try to access it, I get an error Labeled "Location is not available" and the error says " E:\ is not accessible

Access is denied."

Please help! one of things I have on there is a ton of pictures from all over the web! It would take me almost littery 20 years to replace it all!

-Update-

A friend has helped a little. He says A Pic had a trojan horses. I am doing scans, and am changing permitions to let me back in, but Windows incountered an error in a file that is labeled "preconfigared" with access denied. This is not good cause I put the items that were already in the drive when I got it in there, and I believe It has a few nessicary files, how do I change it so I can get in!?

-update-

OK, I'm in, but I have a few files that I keep getting "access is denied" errors. How do I get access?! I'm the owner of the File too!

[Digital-Punk]

I personally would run a virus scan on that drive and see what you find for starters. Then post your scan here so we can look at it.

[Aelita]

I did, with two different anti-virus programs, and neither found anything.

[Digital-Punk]

What anit-virus programs did you use If you dont mind me asking?

[Aelita]

'Malwarebyte' and 'Avast!'....

[Digital-Punk]

What kinda of files are getting accessed denied errors?

[Aelita]

Um, Different kinds, but the ones I am most conserned about have pictures, and a few documents. But I did manage to get change the permitions of Of some of them, One file at a time.

[Digital-Punk]

So when you change the file permissions you are able to use the file? If so, instead of doing it one by one check this link http://www.tek-tips.com/viewthread.cfm?qid=1300502 If you dont have any virus's on that drive I would write a batch script to change all the file permissions.

[Aelita]

I don't know If I do not have any virus, as some can escape detection, but being in safe mode seems to let me to it all at once.

[MineCrack]

If you can recover your pictures in safe mode, I recommend salvaging all the files you think are important (and you can't get back). Then, scanning with malwarebytes one more time. After that, make a new profile then give it admin rights (All in the control panel, should be managing account, I don't quite remember but I did have a vista for 5 years). Then change your profile to standerd user, restart your computer login to the new user account. After that, delete your old profile as you please =D!